Protandim Nrf2 Synergizer

What is Protandim Nrf2 Synergizer?

Nrf2 Synergizer from Protandim is designed to allegedly help jumpstart your body’s ability to produce antioxidants.

According to Protandim, this is accomplished by boosting Nrf2, an enzyme that increases the expression of antioxidants to promote anti-inflammation, protective, and healing capabilities.

Antioxidants help fight off free radicals, molecules that cause the oxidative stress that is associated with a wide variety of adverse health. This is an important role as avoiding free radicals is impossible as they are generated by vital functions like eating, breathing, and exercising.

Protandim states that by taking 1 capsule daily, Nrf2 Synergizer will:

• Help you detox genes
• Reduce oxidative stress by as much as 40% in 1-month
• Activate Nrf2 to decrease cellular stress
• Produce enzymes that neutralize free radicals
• Regulate survival genes
• Help your body repair and rejuvenate its own cells

According to the website, science backs up these purported benefits.

In this article, we’ll help you determine if Nrf2 Synergizer can offer the proposed benefits by reviewing the details of Protandim’s clinical studies.

The Nrf2 Synergizer Active Ingredients: Do They Work?

Protandim’s Nrf2 Synergizer is alleged to jump-starting your body’s ability to produce antioxidants through a blend of natural ingredients.

According to the Supplement Facts label, every capsule of Nrf2 Synergizer contains the following:

Calcium - 77mg

Proprietary Blend - 675mg

• Milk Thistle Extract - Despite its name, milk thistle does not contain dairy. The extract has been used in formulations that claim to offer detoxifying benefits.
• Bacopa Extract - Bacopa is a tropical herb that may boost brain function, relieve inflammation, and fight free radicals.
• Ashwagandha Extract - Ashwagandha is found in India and may improve memory, boost immunity, and offer antioxidant benefits.
• Green Tea Extract - A common dietary supplement ingredient, green tea may offer a variety of health benefits through its caffeine and antioxidant content.
• Turmeric Extract - This spice has been used for centuries in food preparation and traditional medicine. Its antioxidant and anti-inflammatory properties are related to its active compound, its active compound, curcumin.

As Nrf2 Synergizer was studied as a stand-alone product, we can use the published research to gain a better understanding of the potential benefits of this supplement, if any.

In 2006, Nrf2 Synergizer (675mg daily) was administered to healthy subjects from 20-78 years of age. After 120-days, the supplement effectively boosted superoxide dismutase (SOD), an important antioxidant.

Researchers also noted that thiobarbituric acid-reacting substances (TBARS) declined during the study duration. TBARS typically increase with age and can be associated with adverse health effects like heart attack and stroke.

In 2009, Nrf2 Synergizer was tested in a laboratory setting. When exposing cultured mouse cells to the supplement, researchers measured an increase in antioxidant enzymes. When given orally to mice with muscular dystrophy, Nrf2 Synergizer cut TBARS nearly in half, though treatment did not improve motor function or microscopic assessments.

In 2011, human blood vessel cells treated with Nrf2 Synergizer had more antioxidant enzyme activity. Most recently, Nrf2 Synergizer was put to the test in rat cells. Researchers concluded that the supplement was able to promote antioxidant activity and protect against free radical damage.

While there are many studies that support the antioxidant-boosting capabilities of Nrf2 Synergize, most of them were completed in a laboratory setting or with animal models.

Despite having at least one study that included human subjects, the significance of increasing SOD levels with Nrf2 Synergizer has not been demonstrated. Much more work is needed to determine the long-term safety and efficacy.

Is Nrf2 Synergizer Safe?

Nrf2 Synergizer contains 5 natural ingredients that are generally safe to use.

While this blend was well tolerated throughout 120-days, this is the only real evidence we have detailing its safety. Without additional research in human subjects, the effects of using this supplement in the long-term are unknown.

You are most likely to experience mild digestive disturbances like stomach pain, diarrhea, nausea, or vomiting. The company does suggest that headache and rash are also possible.

Though these symptoms should disappear by reducing your dose or discontinuing use, you should speak to your doctor before trying new supplements.

The Cost

Protandim’s Nrf2 Synergizer is available directly from the product page with a few purchasing options.

You can place a one-time order for a 1 or 3-pack; they are priced at $59.99 and $150.99, respectively. Shipping is free on orders of more than $100.

You can also opt for a subscription to save further. Your 1-pack ships monthly and you're auto-billed $49.99. The 3-pack ships every 3-months for $125.99.

A 30-day guarantee backs your purchase. To process your return, contact support at 866-460-7241 or email the company at support@lifevantage.com.

You can also find a 1-month supply at Amazon for $40.65, and they also offer 30-day returns.

What Are the Alternatives to Nrf2 Synergizer?

While there are many anti-aging supplements available on the market, Nrf2 Synergizer’s blend is less common. In fact, our research didn’t reveal any other supplements that provided the exact ingredients.

At HighYa, we have previously reviewed other anti-aging products that claim to work at the cellular level. Basis by Elysium is one example.

While the benefits of these 2 supplements are similar, Basis claims to achieve them by boosting your Nicotinamide adenine dinucleotide (NAD+). This molecule plays a major role in how your body creates energy.

Basis combines pterostilbene and nicotinamide riboside, so you won’t find any of the Nrf2 Synergizer ingredients. As you’ll pay $60 for a 1-month supply, you wouldn’t save money with this product.

Also, the research does demonstrate an ability to boost NAD+. However, there’s no evidence for what the real-world implications of this mean. Until research demonstrates tangible benefits, you may want to save your money.

If you’re interested in Nrf2 Synergizer’s specific blend, Ayurvedic Brain Health Support is a closer match. Though they claim to boost mental function. This supplement contains bacopa, ashwagandha, and turmeric for just $11.99 for a 45-day supply.

This is a much more cost-effective option, even if you figure in the expense of adding green tea and milk thistle.

The Bottom Line

Protandim’s Nrf2 Synergizer contains a blend of ingredients that have demonstrated the ability to boost antioxidant activity, though most of the support is in laboratory and animal models.

There is at least one human trial that also backs this benefit, though there isn’t any evidence that describes what anti-aging effects are possible.

Nonetheless, at Amazon, 66 customers rate Nrf2 Synergizer 4.3-stars. Those pleased with the results mention benefits like less pain and more energy, as well as less hot flashes and improved vertigo.

Users seem generally pleased, though the benefits they cite are vague. As Nrf2 Synergizer is costly and lacks strong scientific support, you should probably save your money.

While aging naturally involves many unavoidable processes, you can maintain your general well-being by starting with a healthy diet and regular exercise.

If you have symptoms that seem beyond regular aging, seek the care of your doctor.